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Literature summary extracted from

  • Wu, Q.; Criscione, K.R.; Grunewald, G.L.; McLeish, M.J.
    Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data (2004), Bioorg. Med. Chem. Lett., 14, 4217-4220.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.28 (R)-7-bromo-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline
-
 Homo sapiens
2.1.1.28 1-(2,3-dichlorophenyl)ethanamine
-
 Homo sapiens
2.1.1.28 3-fluoromethyl-7-iodo-1,2,3,4-tetrahydroisoquinoline
-
 Homo sapiens
2.1.1.28 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
-
 Homo sapiens
2.1.1.28 7-sulfonamido-1,2,3,4-tetrahydroisoquinoline
-
 Homo sapiens
2.1.1.28 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine
-
 Homo sapiens
2.1.1.28 N-(4-chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
-
 Homo sapiens
2.1.1.28 R-(+)-7-bromo-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.28 Homo sapiens
-
-
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.28 0.0000031
-
 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline pH 8.0 Homo sapiens
2.1.1.28 0.0000049
-
 R-(+)-7-bromo-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline pH 8.0 Homo sapiens
2.1.1.28 0.000012
-
 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine pH 8.0 Homo sapiens
2.1.1.28 0.000073
-
 3-fluoromethyl-7-iodo-1,2,3,4-tetrahydroisoquinoline pH 8.0 Homo sapiens
2.1.1.28 0.00009
-
 1-(2,3-dichlorophenyl)ethanamine pH 8.0 Homo sapiens
2.1.1.28 0.00027
-
 N-(4-chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide pH 8.0 Homo sapiens
2.1.1.28 0.00028
-
 7-sulfonamido-1,2,3,4-tetrahydroisoquinoline pH 8.0 Homo sapiens